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If you're going to the Colosseum, try to get on one of the organized tours. There are loads of people touting for business all around the Colosseum. The benefits are two fold, one you generally jump straight to the front of the queue and secondly their fairly entertaining. Ask if you can meet/speak with the guide prior to signing up. That way you can suss out if they're any good. Also ask what the maximum capacity of the group is. We didn't and there were that many people in the group everyone had to charge between stops to find a spot where we could actually hear her speak!
We spent all afternoon chillin' in Piazza Navona doing absolutely nothing. After a 3 course lunch followed by gelati we ordered in a couple of bottles of vino and just watched the world go by. Even now as I'm chained to my desk I can still feel the sun on my back. Bliss